By Jacques Donnez MD PhD, S. Samuel Kim
The area of expertise of fertility upkeep deals sufferers with melanoma, who're rendered infertile via chemo- and radiotherapy, the chance to gain their reproductive capability. This gold-standard booklet defines the distinctiveness. the whole diversity of innovations and clinical strategies is roofed intimately, and the writer group contains a number of the world's prime specialists within the box. The ebook opens with introductions to fertility maintenance in either melanoma and non-cancer sufferers, through melanoma biology, epidemiology and remedy, and reproductive biology and cryobiology. next sections disguise fertility upkeep options in ladies and men, together with medical/surgical techniques, artwork, cryopreservation and transplantation of either ovarian tissue and the total ovary, and in-vitro follicle development and maturation. Concluding chapters deal with destiny applied sciences, in addition to moral, felony and spiritual concerns. Richly illustrated all through, this can be a key source for all clinicians focusing on reproductive medication, gynecology, oncology, hematology, endocrinology and infertility.
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Additional resources for Principles and Practice of Fertility Preservation
To become widely accepted, these procedures need to be safe, easy to perform and with favorable results. Meanwhile, a combination of ovarian cryopreserved transplantation, further ovarian stimulation and vitrification of the retrieved oocytes to be accumulated for an in vitro fertilization (IVF) cycle can be used. A twin pregnancy was recently obtained through this method . antral follicles and their evolution to antral follicles was demonstrated. Thus, GnRHa could avoid follicles reaching their sensitivity threshold to chemotherapy by supression of the granulosa cells.
Lie Fong S, Lugtenburg PJ, Schipper I et al. Anti-M¨ullerian hormone as a marker of ovarian function in women after chemotherapy and radiotherapy for haematological malignancies. Hum Reprod 2008; 23: 674–8. 23. Rosendahl M, Andersen CY, la Cour Freiesleben N et al. Dynamics and mechanisms of 19 Section 1: Introduction chemotherapy-induced ovarian follicular depletion in women of fertile age. Fertil Steril 2010; 94(1): 156–66. 24. Sklar CA, Mertens AC, Mitby P et al. Premature menopause in survivors of childhood cancer: a report from the childhood cancer survivor study.
Larsen EC, Schmiegelow K, Rechnitzer C et al. Radiotherapy at a young age reduces uterine volume of childhood cancer survivors. Acta Obstet Gynecol Scand 2004; 83: 96–102. 66. Shalet SM, Tsatsoulis A, Whitehead E and Read G. Vulnerability of the human Leydig cell to radiation damage is dependent upon age. J Endocrinol 1989; 120: 161–5. 67. Castillo LA, Craft AW, Kernahan J, Evans RG and Aynsley-Green A. Gonadal function after 12-Gy testicular irradiation in childhood acute lymphoblastic leukaemia.