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Opin. Struct. Biol. 15, 313–323 (2005). 5. Yarus, M. & Knight, R. in The Genetic Code and the Origin of Life (ed. ) 75–91 (Landes Bioscience, Georgetown, Texas, 2004). 6. Yarus, M. Annu. Rev. Biochem. 74, 179–198 (2005). 7. Tarasow, T. , Tarasow, S. L. & Eaton, B. E. Nature 389, 54–57 (1997). 8. Lawrence, M. S. & Bartel, D. P. RNA 11, 1173–1180 (2005). 9. Yarus, M. Cold Spring Harb. Symp. Quant. Biol. 66, 207–215 (2001). Correction In “Ecology: Roots of stability” by Peter D. Moore (Nature 437, 959–961; 2005), the reference to the main paper discussed was incorrect.

This cohort study brought independent confirmation of studies of Japanese A-bomb survivors that radiation could cause leukaemia, and it has been a major source of data on the dose–response relation of radiation and cancer. In another project, British radiologists were investigated because of their repeated exposure to low doses of radiation, the only group with excess cancer being those with long practice in the early twentieth century when high cumulative doses were likely as a result of the relative lack of protective procedures.

In support of this, a number of RNA enzymes (ribozymes) have been created, or captured from the wild, that can carry out the sorts of chemical reaction — the formation of peptide bonds, for example — that would have been necessary for such life. Now Fusz et al. identify a ribozyme that can catalyse the particularly tricky aldol reaction. This involves carbon–carbon bond formation which would have been required at several significant points in the evolution of life, including, possibly, when ribose was first produced.

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