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Extra resources for Nature Reviews Microbiology (January 2008 Vol 6 No 1)
Antibacterial lysine analogs that target lysine riboswitches. Nature Chem. Biol. 3, 44–49 (2007). Identified lysine analogues that bind to lysine riboswitches in vitro and inhibit the growth of Bacillus subtilis. Also discusses the general importance of riboswitches and their suitability as antibacterial drug targets. D. The antibiotic resistome: the nexus of chemical and genetic diversity. Nature Rev. Microbiol. 5, 175–186 (2007). M. et al. Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing.
10, 712–717 (2006). 79. , Lam, K. W. Production of mucoid microcolonies by Pseudomonas aeruginosa within infected lungs in cystic fibrosis. Infect. Immun. 28, 546–556 (1980). 80. K. et al. Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature 407, 762–764 (2000). 81. Benghezal, M. et al. Inhibitors of bacterial virulence identified in a surrogate host model. Cell. Microbiol. 9, 1336–1342 (2007). 82. Keller, L. G. Communication in bacteria: an ecological and evolutionary perspective.
Elofsson, M. Small-molecule inhibitors specifically targeting type III secretion. Infect. Immun. 73, 3104–3114 (2005). 73. Wolf, K. et al. Treatment of Chlamydia trachomatis with a small molecule inhibitor of the Yersinia type III secretion system disrupts progression of the chlamydial developmental cycle. Mol. Microbiol. 61, 1543–1555 (2006). 74. Muschiol, S. et al. A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis. Proc.