Download Modelling the Short QT Syndrome Gene Mutations: And Their by Ismail Adeniran PDF

By Ismail Adeniran

The brief QT Syndrome (SQTS) is characterised by means of abbreviated QT durations at the electrocardiogram, elevated threat of cardiac arrhythmias and surprising demise. even supposing numerous gene mutations were pointed out in SQT sufferers, the position of those mutations in selling arrhythmogenesis remains to be no longer thoroughly understood. as a result, this thesis employs multidisciplinary techniques to enhance a 3D digital middle, that's then used to clarify how the fast QT syndrome allows and continues ventricular arrhythmias and to figure out its results on ventricular mechanical contraction. The findings during this thesis supply a accomplished and mechanistic reason for a couple of gene mutations linked to potassium channels when it comes to susceptibility to arrhythmia. The multiphysics versions constructed offer a strong platform for determining the basis motives of varied arrhythmias and investigating healing interventions for those diseases.

The thesis was once tested via Prof. Chris Huang of the collage of Cambridge, the main authoritative determine in cardiac electrophysiology, who has defined the paintings as “outstanding.”

Show description

Read Online or Download Modelling the Short QT Syndrome Gene Mutations: And Their Role in Cardiac Arrhythmogenesis PDF

Similar cardiology books

Aortic Root Surgery: The Biological Solution

The surgical result of bioprosthetic aortic valve substitute within the Sixties and Seventies weren't very passable. the hunt for the suitable replacement for the diseased aortic valve led Donald Ross to advance the concept that of the aortic allograft in 1962 and the pulmonary autograft in 1967 for subcoronary implantation, and later, in 1972, as an entire root for changing the aortic root within the contaminated aortic valve with a root abscess.

Aging Issues in Cardiology

Getting older concerns in Cardiology offers an outline of the sensible scientific parts fascinated by dealing with heart problems within the aged. This quantity may be helpful to any doctor handling the cardiovascular overall healthiness of aged participants. themes coated contain: -Delirium in aged Cardiac Patients,-Depression, - Pharmacologic concerns, - fundamental Prevention, - Syncope, - center Failure, - Coronary Revascularization.

Modelling the Short QT Syndrome Gene Mutations: And Their Role in Cardiac Arrhythmogenesis

The quick QT Syndrome (SQTS) is characterised via abbreviated QT periods at the electrocardiogram, elevated chance of cardiac arrhythmias and surprising demise. even supposing numerous gene mutations were pointed out in SQT sufferers, the function of those mutations in selling arrhythmogenesis continues to be no longer thoroughly understood.

Atherothrombosis and coronary artery disease

Written by way of the world’s most suitable specialists, this quantity offers complete insurance of present ways to the prevention, prognosis, and administration of atherothrombosis and its coronary and noncoronary problems. This variation has been completely up-to-date, sharply keen on medical info, and trimmed to 1 doable quantity.

Additional resources for Modelling the Short QT Syndrome Gene Mutations: And Their Role in Cardiac Arrhythmogenesis

Sample text

It consequently protects the heart by shortening the APD, reducing excitability and moving the membrane potential closer to the K+ equilibrium potential. Channels for IK,ATP are very selective for K+ ions [22, 24, 57]. 8 Stretch-Activated Channels A sequence of electrical excitation waves propagating in the heart trigger its mechanical contraction. This is known as excitation-contraction coupling [25, 57]. In response to changes in volume load or contractile function, the heart is able to regulate its cellular electrical activity [83–86].

Franz MR (1996) Mechano-electrical feedback in ventricular myocardium. Cardiovasc Res 32(1):15–24 84. Lab MJ (1982) Contraction-excitation feedback in myocardium. Physiological basis and clinical relevance. Circ Res 50(6):757–766 85. Lab MJ (1996) Mechanoelectric feedback (transduction) in heart: concepts and implications. Cardiovasc Res 32(1):3–14 86. Youm JB, Han J, Kim N, Zhang Y-H, Kim E, Leem CH et al (2005) Role of stretchactivated channels in the heart: action potential and Ca2 + transients—mechanosensitivity in cells and tissues—NCBI Bookshelf.

Biochem Biophys Res Commun 334(2):441–449 80. 5 mRNA specifically inhibit ultrarapid delayed rectifier K + current in cultured adult human atrial myocytes. Circ Res 80(4):572–579 81. Wang Z, Fermini B, Nattel S (1993) Sustained depolarization-induced outward current in human atrial myocytes. 5 cloned channel currents. Circ Res 73(6):1061–1076 82. Amos GJ, Wettwer E, Metzger F, Li Q, Himmel HM, Ravens U (1996) Differences between outward currents of human atrial and subepicardial ventricular myocytes.

Download PDF sample

Rated 4.45 of 5 – based on 30 votes