Download Leptin by V. Daniel Castracane, Michael C. Henson (auth.), V. Daniel PDF

By V. Daniel Castracane, Michael C. Henson (auth.), V. Daniel Castracane PhD, Michael C. Henson PhD (eds.)

The discovery of leptin little greater than a decade in the past, as a hormone produced in white adipose tissue with a massive position in satiety and effort expenditure, used to be a seminal occasion in our realizing of adiposity. This preliminary strengthen within the new endocrinology of weight problems was once quickly via the conclusion that leptin used to be not just produced in adipose tissue, yet in lots of various tissues of the physique, and that receptors have been equally dispensed. also, the early reputation of infertility that was once linked to leptin deficiency brought on learn that pointed out roles for the polypeptide in nearly each zone of reproductive biology.

A common curiosity in leptin has quickly produced inroads into unforeseen components of body structure that can ultimately elucidate the numerous relationships of adiposity to human health and wellbeing and disorder. those advancements were paralleled via a rigorous research as a fabricated from pharmaceutical curiosity. The vast diversity of body structure and the scientific events during which leptin is now implicated is reviewed for the 1st time within the current volume.

***Series Editor's comments****

This quantity integrates leading edge easy and scientific details encompassing the expression of leptin and leptin receptors, pathophysiology and scientific position of leptin- a brand new neuroendocrine hormone with pleiotropic roles in urge for food rules, metabolic, inflammatory, neoplastic, cardiovascular and reproductive services.

This unmarried quantity encyclopedic assurance is critical to scholars, postdoctoral trainees, fellows, scientists and practitioners attracted to neuroendocrine peptide keep watch over of a number of mobile functions.

Shlomo Melmed, M.D.
Series Editor
Endocrine Updates

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Extra resources for Leptin

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Tataranni, The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism. Int J Obes Relat Metab Disord, 26, 1629-32 (2002). 135. A. Takahashi-Yasuno, H. Masuzaki, T. Miyawaki, Y. Ogawa, N. Matsuoka, T. Hayashi, K. Hosoda, G. Inoue, Y. Yoshimasa, and K. Nakao, Leptin receptor polymorphism is associated with serum lipid levels and impairment of cholesterol lowering effect by simvastatin in Japanese men. Diabetes Res Clin Pract, 62, 169-75 (2003).

Mol Endocrinol, 19, 925-38 (2005). Leptin receptors 25 48. A. Lothgren, M. McCartney, E. Rupp Thuresson, and S. R. James, A model of activation of tiie protein tyrosine phosphatase SHP-2 by the human leptin receptor. Biochim Biophys Acta. 1545, 20-9 (2001). 49. O. Gualilio, S. Eiras, D. W. White, C. Dieguez, C. and F. F. Casanueva, Leptin promotes the tyrosine phosphorylation of SHC proteins and SHC association with GRB2. Mol Cell Endocrinol, 190, 83-9 (2002). 50. T. Yamashita, T. Murakami, S. Otani, M.

Bottner, A. Glasow, and J. Kratzsch, Soluble leptin receptor represents the main leptin binding activity in human blood. Biochem BiophysRes Commun, 283, 982-8 (2001). 114. A. Lammert, G. Brockmann, U. Renne, W. Kiess, A. Bottner, J. Thiery, and J. Kratzsch, Different isoforms of the soluble leptin receptor in non-pregnant and pregnant mice. Biochem Biophys Res Commun, 298, 798-804 (2002). 115. G. Yang, H. Ge, A. Boucher, X. Yu, and C. Li, Modulation of direct leptin signaling by soluble leptin receptor.

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