Download Kidney : Toxicological Assessment by Sang Geon Kim PDF

By Sang Geon Kim

Bridging the space among advances in simple biology and chemistry and technological functions within the box of toxicity tests, this ebook describes significant parts of development within the laboratory and medical institution. within the first part, facets of mobile organelles are mentioned. the second one part covers the fundamental ideas and functions of recent toxicological instruments resembling transcriptomic, proteomic, and metabolomic methods. within the 3rd part, the hot advancements on molecular modeling and platforms biology are defined with a watch at the destiny institution of digital mobilephone expertise. ultimately, the booklet discusses scientific implications of acute and protracted renal toxicity.

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Following clinical research that confirmed the original findings, the PSTC NWG submitted KIM-1 as a nephrotoxicity biomarker to the FDA/EMEA (54, 55). - Clusterin Blaschuk, Burdzy, and Fritz isolated clusterin from ram rete testes in 1983 (56). In the early 1990s, a few studies reported an association between clusterin expression and nephrotoxicity (57–60). Injured kidneys express high levels of clusterin mRNA and protein in various models (61, 62). However, clusterin is a biomarker for other diseases, in particular Alzheimer’s disease (63).

Nan Fang Yi Ke Da Xue Xue Bao. 28: 389–91. 71. Guo CX, Li YB, Du HY et al. 2008. Effects of over-expressed Smac gene coupling with cisplatin on proliferation and apoptosis of hepatocarcinoma cells. Zhonghua Gan Zang Bing Za Zhi. 16: 674–7. 72. Golovine K, Makhov P, Uzzo RG et al. 2010. Cadmium down-regulates expression of XIAP at the post-transcriptional level in prostate cancer cells through an NF-kappaBindependent, proteasome-mediated mechanism. Mol Cancer 9: 183. 73. Samuel T, Welsh K, Lober T et al.

The procedures for the proteome analysis. 44 Kidney: Toxicological Assessment Proteomic Approaches to Toxicity Assessment 45 Fig. 2. Flow Chart of Proteome Research. regarding the protein coverage were idenfied. Recently, improved protein coverage has been obtained through gel-free methods (22). To determine the proteome composition of a protein complex, protein detection in a complex mixture is necessary. Gel electrophoresis is a common gel-based technique that has been traditionally used in the field of protein separation studies.

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