By Karen H. Lu
Hereditary Gynecologic melanoma: chance, Prevention and Management fills the necessity that exists for a ebook addressing hugely appropriate scientific matters linked to the recent box of hereditary gynecologic cancers. Written with the clinician in brain, the authors will hide a large diversity of issues, starting with an summary discussing scientific relevance of hereditary ovarian and hereditary endometrial cancers. Succeeding sections will offer in-depth analyses of Hereditary Breast Ovarian melanoma Syndrome, Lynch Syndrome, and different syndromes with gynecologic melanoma elements, and genetic danger assessment.
Hereditary Gynecologic melanoma: possibility, Prevention and Management :
- is the 1st clinically concentrated reference detailing gynecologic sufferer administration problems with BRCA1 and BRCA2 mutation carriers
- includes a pragmatic part on genetic hazard evaluate and genetic testing
- examines case reviews to illustrate administration options and decision-making
- provides specified dialogue of ovarian melanoma screening, prevention and probability decreasing surgery
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Additional resources for Hereditary Gynecologic Cancer: Risk, Prevention and Management
Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 1994; 368(6468):258–261. 12. Fishel R, Lescoe MK, Rao MR, et al. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 1993; 75(5):1027–1038. 13. Leach FS, Nicolaides NC, Papadopoulos N, et al. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 1993; 75(6):1215–1225. 14. Hendriks YM, Jagmohan-Changur S, van der Klift HM, et al.
In the group of women who had an endometrial cancer first, there was a median time of 11 years before the diagnosis of the gastrointestinal cancer. Gynecologic oncologists clearly need to play a crucial role in identifying an endometrial cancer patient as having Lynch syndrome. In addition, there appears to be time to refer the patient to genetic counseling and testing and subsequently to institute screening recommendations to decrease colon cancer risk. Synchronous endometrial and ovarian cancers are not uncommon and occur in about 10% of all ovarian cancers and in 5% of all endometrial cancers.
Am J Hum Genet 2003; 72(5): 1117–1130. 24. King MC, Marks JH, Mandell JB, and New York Breast Cancer Study Group. Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. Science 2003; 302(5645):643–646. 25. Dunlop MG, Farrington SM, Carothers AD, et al. Cancer risk associated with germline DNA mismatch repair gene mutations. Hum Mol Genet 1997; 6:105–110. 26. Aarnio M, Sankila R, Pukkala E, et al. Cancer risk in mutation carriers of DNAmismatch-repair genes. Int J Cancer 1999; 81:214–218.