By Nao Suzuki, Jacques Donnez
This publication is a realistic consultant to the cryopreservation and transplantation of oocytes, embryos, and ovarian and testicular tissue for fertility renovation. Illustrated with a wealth of figures and pictures, it presents up to date thoughts for clinicians, technicians, and researchers. This e-book additionally offers insights into in vitro activation (IVA), in vitro becoming (IVG), and in vitro maturation (IVM), with either easy study and destiny instructions. those concepts mixed with cryopreservation will enhance the possibilities of copy. Cryopreservation is vital to guard fertility in melanoma sufferers who suffer therapy with radioiodine or chemotherapy, which could reason harm to their reproductive organs, and likewise for fundamental ovarian insufficiency sufferers. The ebook additionally contains a bankruptcy at the danger of the presence of malignant cells in ovarian tissue. either editors are pioneering researchers during this field.
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Additional resources for Gonadal Tissue Cryopreservation in Fertility Preservation
Sonmezer M, Turkcuoglu I, Coskun U, Oktay K (2011) Random-start controlled ovarian hyperstimulation for emergency fertility preservation in letrozole cycles. Fertil Steril 95 (6):2125, e2129–2111 21. Bedoschi GM, de Albuquerque FO, Ferriani RA, Navarro PA (2010) Ovarian stimulation during the luteal phase for fertility preservation of cancer patients: case reports and review of the literature. J Assist Reprod Genet 27(8):491–494 22. Nayak SR, Wakim AN (2011) Random-start gonadotropin-releasing hormone (GnRH) antagonist-treated cycles with GnRH agonist trigger for fertility preservation.
If the patient has known hypothalamic dysfunction and has high risk of OHSS, in our limited clinical experience, very low dose hCG (1,500 IU) trigger with FSH supplementation (450 IU) at the time of trigger can be an alternative without negatively impacting the mature oocyte yield. The number of follicles in combination with serum estradiol levels predicts OHSS with high sensitivity and specificity [71, 72]. However, co-treatment with aromatase inhibitors limits the utilization of serum estradiol level to predict OHSS.
In a recent study, it was demonstrated that the pregnancy outcomes of frozen embryo transfers with embryos generated after ovarian stimulation with letrozole in patients with breast cancer were comparable (65 % clinical pregnancy rate (26 of 40) with 45 % live birth rate (18 of 40)) to those of infertile women in the same age category . 8 % (7 of 18) were twins. 3 weeks. Additionally, after a mean follow-up of more than 3 years, no minor or major fetal malformations or developmental abnormalities were observed in the newborn .