By B. Runnebaum, T. Rabe, L. Kiesel
Atrophy of gonadotrophin generating cells Exogenously LH synthesis administered androgens and unencumber or anabolic steroids are lowered Prostate Testes basic functionality. Testosterone synthesis within the deficit of endogenously Leydig cells is reduced. The synthesized testosterone is exogenously administered compensated for by means of the steroid isn't really in a position to exogenously administered atone for the deficit of steroid endogenously synthesized testosterone determine 2 Intratesticular and serum testosterone concentrations after remedy with andro gens or anabolic steroids with a purpose to alternative for the peripheral androgen deficiency and to accomplish azoospermia. simply because this steroid is alkylated in place 17, poisonous results on liver functionality can't be excluded. Danazol deals no benefits in comparison with different anabolic steroids; particularly, risks. a variety of experiments of this sort were played over the past forty or 50 years. the result in every one case used to be roughly exact: with a undeniable dose of an androgen or anabolic steroid it's attainable to inhibit spermatogenesis with no interfering with different androgen-dependent func tions, together with libido (potentia coeundi) and accent sexual glands. at the foundation of this pharmacological-endocrinological historical past, androgens and anabolic steroids can be utilized for male fertility keep watch over, and several other scientific trials were played over the past 10-15 years. a few of 1 those stories 2-23 are pointed out in desk 2.
Read Online or Download Future Aspects in Contraception: Proceeding of an International Symposium held in Heidelberg, 5–8 September 1984 Part 1 Male Contraception PDF
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Extra info for Future Aspects in Contraception: Proceeding of an International Symposium held in Heidelberg, 5–8 September 1984 Part 1 Male Contraception
Recent studies have shown that the beta-blocking propranolol can also be used as a locally effective spermatocide. Propranolol has been investigated in its steric as well as in its D-isomeric form and has been proved to be an effective inhibitor of sperm motility. Propranolol is resorbed by the vagina and, in addition, is, in small amounts, secreted by the sperms. , 1983). The role of benzalkonium chloride as a spermatocide cannot be evaluated at present. Recent studies of benzalkonium chloride (Pharmatex Cones) have been published by Barwin (1983) and by Erny et al.
The advantage of this method lies in the fact that it is, unlike oral contraceptives and intrauterine devices, only used when necessary and not over a period. Also, the diaphragm is cheap and can be used for a long time. A disadvantage is the 34 FUTURE ASPECTS IN CONTRACEPTION Symphysis Figure 26 Correct position for diaphragm fact that it must remain in place for up to 8 h after intercourse and the patient is not allowed to have a bath during that time. Cervical cap The cervical cap also is a mechanical barrier, which covers the cervix like a thimble (Figure 27).
27 AN OVERVIEW positive feedback= receptor induction negative feedback= receptor down regulation time Figure 20 Changes in the receptors according to hormone stimulation. In the presence of a low hormone concentration the number of receptors increases as a result of receptor induction; down-regulation of the receptors can be achieved by prolonged stimulation The administration of antagonists seemed to be a logical approach to the blockade of gonadotrophin release. Paradoxically, however, the agonistsoriginally developed for the treatment of infertile patients-show strong inhibitory effects.