Download Developmental Origins of Health and Disease by Peter Gluckman, Mark Hanson PDF

By Peter Gluckman, Mark Hanson

This landmark ebook presents the 1st definitive account of the way and why sophisticated impacts at the fetus and through adolescence may have such profound effects for grownup wellbeing and fitness and ailments. even though the epidemiological proof for this hyperlink has lengthy proved compelling, it's only even more lately that the medical and physiological foundation has all started to be studied intensive and completely understood. The compilation, written through a few of the world's prime specialists during this interesting box, summarizes those clinical and medical advances.

Show description

Read Online or Download Developmental Origins of Health and Disease PDF

Best obstetrics & gynecology books

An atlas of gynecologic oncology

(Martin Dunitz) ny Univ. , manhattan urban. Atlas for postgraduates fascinated about the surgical administration of gynecological malignancy. contains a complete description of nearly all of investigative and surgeries required of the gynecological oncologist. supplies transparent written and pictorial guideline.

Berek & Novak's Gynecology (Berek and Novak's Gynecology)

The best textual content in gynecology is in its Fourteenth variation, completely revised and up-to-date and now in complete colour all through. prepared into 8 sections, this accomplished and common gynecological textbook presents counsel for the administration of particular gynecological stipulations. the 1st sections hide ideas of perform and preliminary evaluate and the appropriate simple technology.

Progestogens in Obstetrics and Gynecology

This ebook brings jointly the main updated information regarding the body structure of progestogens. This quantity addresses the bidirectional conversation among hormones, fertility, tumors, and autoimmunity. It presents the elemental technology and medical views of progestogens that have now not been formerly to be had in a single quantity.

Drugs During Pregnancy: Methodological Aspects

This publication addresses methodological facets of epidemiological reports on maternal drug use in being pregnant. Discussing the prevailing assets of mistakes and the way they could produce fallacious conclusions, it examines a number of epidemiological concepts and assesses their strengths and weaknesses. those refer either to the identity of results (with targeted emphasis on congenital malformations) and to the kinds of publicity (drug use).

Extra resources for Developmental Origins of Health and Disease

Example text

1994). The increased risk of diabetes among those of high birthweight was associated with maternal diabetes in pregnancy. Both deficiency in insulin production and insulin resistance are thought to be important in the pathogenesis of type 2 diabetes. There is evidence that both may be determined in fetal life. As discussed further in Chapter 16, infants who are small for dates have fewer pancreatic β cells and there is evidence that nutritional and other factors determining fetal and infant growth influence the size and function of the adult β cell complement (Hales and Barker 1992).

Although nutrition has received the most focus (Langley and Jackson 1994, Vickers et al. 2000, Bertram and Hanson 2001), other early environmental factors such as infection, season of birth (Doblhammer and Vaupel 2001) and smoking (Power and Jefferis 2002) may also have long-term effects. We have proposed that the mechanisms through which maternal influences lead to developmental plastic responses include (a) a mismatch between fetal nutrient demands, largely determined by the growth trajectory set in early pregnancy, and the maternoplacental capacity to meet this demand, (b) alterations in the fetal endocrine milieu, and (c) changes in placental vascular impedance, which impact on fetal cardiovascular loading.

O. (1991). Relation of birth weight and childhood respiratory infection to adult lung function and death from chronic obstructive airways disease. BMJ, 303, 671–5. Conclusion Degenerative diseases, including cardiovascular disease, type 2 diabetes, osteoporosis and obstructive airways disease, have higher rates among poorer people and cause much disability in both developed and developing communities. The evidence that links the combination of poor maternal nutrition, impaired fetal/infant development and increased weight gain in early childhood to later cardiovascular disease is now strong.

Download PDF sample

Rated 4.22 of 5 – based on 25 votes