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By Francesco Collamati

This thesis specializes in a singular radio-guided surgical procedure method for whole tumor resections. It describes all features of the intraoperative probe, in addition to checking out and simulation of the unconventional procedure. The presentation develops the process from the preliminary proposal to sensible feasibility reviews which were the topic of an announcement of the yank Society of Nuclear medication. only a 12 months after finishing this paintings, the method has now been proven for the 1st time on a meningioma sufferer, confirming all the predictions made during this thesis.

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Stekhanov, MYu. Yablokov, M. Surin, A. Zav’Yalov, Development of VUV wavelength shifter for the use with a visible light photodetector in noble gas filled detectors. Nucl. Instrum. Methods Phys. Res. A 695, 403 (2012) 2. Y. V. S. A. V. A. V. G. N. A. N. M. A. Yu. Yablokov, Detection of scintillation light in liquid xenon by multipixel avalanche Geiger photodiode and wavelength shifter. J. Instrum. 5 (2010) References 51 3. M. Angelone, G. Battistoni, F. Bellini, V. Bocci, F. D. Lucia, R. Faccini, F.

R. Selverstone, B. SweetWH, Theclinical useof radioactive phosphorus in the surgeryof brain tumors. Ann. Surg. 130, 643–651 (1949) 20. V. Ambrosini, M. Fani, S. Fanti, F. R. Maecke, Radiopeptide imaging and therapy in Europe. J. Nucl. Med. Off. Publ. Soc. Nucl. Med. 52(Suppl 2), 42S–55S (2011) 21. M. Cremonesi, M. Ferrari, S. Zoboli, M. G. Stabin, F. R. Maecke, E. Jermann, C. Robertson, M. Fiorenza, G. Tosi, G. Paganelli, Biokinetics and dosimetry in patients administered with (111)in-dota-tyr(3)-octreotide: implications for internal radiotherapy with (90)y-dotatoc.

6) The Birks’ law is an experimental formula that gives the light yield per path length as a function of the energy loss per path length for a particle traversing a scintillator. The relation is: Fig. 8 Measured PMT gain as a function of the bias HV, on log–log scale. 7) where L 0 and k B are constants depending on the material [5]. 9 mg cm−2 MeV−1 . This value is in the range of the values obtained for various organic scintillators ([6] and references therein). It should be noted that a variation in the dopant concentration will modify the quenching mechanisms occurring in the scintillator and thus the measured quenching factor.

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